Robert (Rory Kinnear) is an extraordinary, ambitious showman surgeon who can take a leg off in 92 seconds. William (Mathew Baynton) is a nervous, kind psychiatrist (then called alienist) looking to transform mental care. John (Tom Basden) is a wild, hedonistic, dentist turned anaesthetist. Caroline (Lydia Leonard) is the headstrong, intelligent wife of Robert, who is determined to fight against the male prejudices and patriarchy of Victorian society to realise her own medical ambition. Finally, there’s Dr Hendrick (Rupert Everett) - The President of the hospital and Physician to Royalty. He hates innovation and young people. And women. And patients.